B Pharma Pharmacy 6th Semester Syllabus

B Pharma Pharmacy 6th Semester Syllabus 

Syllabus

SIXTH SEMESTER


BOP-361

PHARMACEUTICAL CHEMISTRY-VI(MEDICINAL CHEMISTRY-II)

Classification, mode of action, uses, recent advances and structure activity relationship of
the following classes of drug (Synthetic procedures of individually mentioned drugs only).

Unit I

Drug design: Basic concepts of drug design, introduction to analogue based drug design,
structure based drug design, introduction to basic concepts of QSAR, molecular descriptors (2Dand 3D parameters), quantitative models, introduction to 2D and 3D QSAR methodologies. 

Unit II

Cardiovascular agents
Antiarrhythmic drugs: Atenolol, Procainamide. 
Antianginal drugs: Isosorbide dinitrate.
 Antihypertensive drugs: Captopril, Amlodipine.
 Antihyperlipedmics: Lovastatin, Clofibrate.

Unit III

Hypoglycaemics: Insulin, Metformin, Tolbutamide, Glibenclamide, Alogliptin. Diuretics: Acetazolamide, Chlorthiazide, Furosemide, Spironolactone.
Thyroid and antithyroids: Carbimazole, Propylthiouracil, Methimazole.

Unit IV

Non steroidal anti-inflammatory drugs (NSAIDS) and analgesics: Aspirin, Paracetamol,
Ibuprofen, Diclofenac, Mefenamic Acid.
Coxibs: Celecoxib.
Anticoagulants: Heparin, Warfarin.

Unit V

Antihistaminics: Diphenhydramine, Chlorpheniramine, Ranitidine. Proton pump inhibitors: Rabeprazole. Cosmeceuticals: Isotretinoin, Minoxidil, Tazarotene.

BOP-361P

PHARMACEUTICAL CHEMISTRY-VI
(MEDICINAL CHEMISTRY-II) PRACTICAL
Synthesis of selected drugs from the course content involving two or more steps and characterize
/establish their Pharmacopoeial standards (if available). Spectral analysis of the synthesized drugs.
1. Synthesis of Paracetamol.
2. To evaluate the Pharmacopoeial standards of Paracetamol.
3. Synthesis of Anthranilic Acid.
4. To characterize the synthesized Anthranilic Acid.
5. Synthesis of antipyrine (2,3-Dimethyl-1-phenyl-pyrazol-5-one).
6. To characterize antipyrine (2,3-Dimethyl-1-phenyl-pyrazol-5-one).
7. Few experiments based on Green Chemistry Approach. 8. To study the Cartesian and internal coordinates for small molecules [MOLDEN (freeware
program)]. 9. To study the architecture of Protein Data Bank (PDB) file.
10. To study the Hansch and Free Wilson analysis (any free statistical program). 11. To study the protein-ligand interaction [AUTODOCK (freeware)]. 12. To develop and validate a 3D-QSAR model [Open3D-QSAR (freeware program) or any
other licensed program].

 BOOKS RECOMMENDED

1. Lemke T.L., Williams D.A., Roche V.F. and Zito S.W., Foyes Principles of Medicinal
Chemistry, Lippincott Williams and Wilkins.
2. Block J.H. and Beale J.M., Wilson and Gisvold’s Textbook of Organic Medicinal and
Pharmaceutical Chemistry, Lippincott Williams and Wilkins.
3. Patrick G.L., An Introduction to Medicinal Chemistry, Oxford University Press.
4. Vardanyan R.S. and Hruby V.J., Synthesis of Essential Drugs, Elsevier.
5. Singh H. and Kapoor V.K., Medicinal and Pharmaceutical Chemistry, Vallabh Prakashan,
Delhi.
6. Abraham D.J., Burger’s Medicinal Chemistry and Drug Discovery, John Wiley and Sons Inc., New York.
7. Jie-Jack Li, Douglas, S. Johnson, Dhago R. Sliskovic, Bruce, D. Roth. Contemporary Drug
Synthesis, John Wiley & Sons Inc.
8. Korolkovas A., Essentials of Medicinal Chemistry, John Wiley and Sons Inc., New York.
9. Pharmacopoeia of India, Ministry of Health, Govt. of India.
10. Lednicer D., The Strategies for Organic Chemistry of Drug Synthesis, John Wiley and Sons
Inc., New York.
11. Burger A., A Guide to the Chemical Basis of Drug Design, A Wiley Interscience Publication
(John Wiley & Sons), New York.
12. Nogrady T., Medicinal Chemistry: A Biochemical Approach, Oxford University Press,
NewYork.
13. Silverman R.B., The Organic Chemistry of Drug Design and Drug Action, Elsevier.
14. Larsen P.K., Liljefors T. and Madsen U. Textbook of Drug Design and Discovery, Taylor
and Francis Inc.
15. Perun T.J. and Propst C.L., Computer-aided Drug Design Methods and Applications, Saurabh
Prakashan Pvt.Ltd., New Delhi.
16. Martin Y.C., Quantitative Drug Design: A Critical Introduction, 2nd Edition, CRC Press,
London.
17. Purcell W.P., Bass G.E., Clayton J.M., Strategy of Drug Design: A Guide to Biological
Activity, PharmaMed Press. 18. Mann F.G. and Saunders B.C., Practical Organic Chemistry, Orient Longman Limited.
19. Furniss B.S., Hannaford A.J., Smith P.W.G. and Tatchell A. R., Vogel’s Textbook of
Practical Organic Chemistry, Dorling Kindersley (India) Pvt. Ltd. (Pearson Education Ltd.).

BOP-362

PHARMACEUTICS-VIII(PHARMACEUTICAL TECHNOLOGY-II)

Unit I

Pharmaceutical polymers: Classification of polymers, synonyms, storage and pharmaceutical
applications of Carbomers, Microcrystalline cellulose, Chitosan, Cyclodextrin, Hydroxypropyl
methyl cellulose, Polyethylene glycol, Polymethyl methacrylate, Polyvinyl pyrrolidone (PVP),
Poly(lactic co-glycolic) acid, Poloxamers.

Unit II

Tablets: Classification, granulation technology on large-scale, physics of tablets making, different
types of tablet compression machinery and the equipment, evaluation of tablets.
Coating of tablets: Types of coating, film forming materials, formulation of coating solution,
equipment for coating process, evaluation of coated tablet.

Unit III

Capsules: Advantages and disadvantages of capsule dosage form, material for production of hard
gelatin capsule, size of capsules, methods of capsule filling. Soft gelatin capsules- preparation and
capsule content, importance of base adsorption and minim/gm factors. Quality control, stability
testing and storage of capsule dosage form.

Unit IV

Controlled and sustained release dosage forms: Basic mechanism of sustained and controlled
release, definition, advantages and limitations of liposomes, niosomes, resealed erythrocytes,
dendrimers, solid lipid nanoparticle (SLN), nano lipid carriers (NLC), implants and transdermal
patches. Micro-particles: Introduction, polymers, methods of preparation (solvent evaporation, spray
drying, emulsion cross linking method), evaluations (particle size, surface characterizations, Poly
dispersity index, entrapment and loading, in-vitro release and release kinetics). 

Unit V

Nanoparticles: Introduction, methods of preparation (emulsion solvent evaporation, double
emulsion solvent evaporation, coacervation-phase separation technique), evaluation (particle size,
surface characterizations, poly dispersity index, entrapment and loading, in-vitro release and
release kinetics).
Packaging of Pharmaceutical Products: Packaging component types, specifications and
methods of evaluation, stability aspects of packaging equipments, factors affecting choice of
containers, legal and other official requirements for containers, package testing.

BOP-362P

PHARMACEUTICS-VIII(PHARMACEUTICAL TECHNOLOGY-II) PRACTICAL

1. Preparation, evaluation and packaging of the following dosage forms containing drugs
mentioned in IP.
a) Capsules. b) Microcapsules and microspheres. c) Tablets. d) Film coated tablets. e) Enteric coated tablets
2. To perform film coating of tablets.
3. To study the gel strength and gelling time of different grades of carbomers and HPMC.
4. To formulate and evaluate sustained release dosage forms. 5. To perform the evaluations of packages (containers and closures) and packaging materials.

BOOKS RECOMMENDED

1. Remington: The Science and Practice of Pharmacy Pharmaceutical Sciences Vol. I and III,
Mack Publishing Company, U.S.A.
2. Avis R.E., Pharmaceutical Dosage Forms: Parenteral Medication, Vol-I, Marcel Dekker-Inc,
New York & Basel.
3. Ansel H.C., Introduction to Pharmaceutical Dosage Forms, Lea & Febiger, Philadelphia,
U.S.A.
4. Khar R. K., Vyas S.P., Ahmad F., Jain G. K., The Theory and Practice of Industrial
Pharmacy, 4
th Edition, CBS Publishers and Distributors. 5. Juliano R.C., Drug Delivery Systems, Oxford University Press, Oxford.
6. Herbert A., Liebermann, Lachman L., Theory and Practice of Industrial Pharmacy, Lea and
Febiger, Philadelphia, U.S.A.
7. Potdar M. A., C-GMP for Pharmaceuticals. 8. Dinda S. C., Advances in Pharmaceutical Technology, PharmaMed Press.
9. Ansel H.C., Pharmaceutical Dosage Form and Drug Delivery System. 10. Sankar, V. Ramesh S., Shanmugam V., A Text book of Novel Drug Delivery System,
PharmaMed Press.
11. Chaurasia M. K., Chaurasia M., Jain N. K., Novel Carriers for Drug Delivery, 1
st Edition,
PharmaMed Press.
12. Rao M.Y., Jithan A.V., Advances in Drug Delivery, Vol. I-III, PharmaMed Press.

BOP-363

PHARMACOLOGY-II

Unit I

Pharmacology of CVS: Cardiac glycosides, antihypertensive drugs, antianginal drugs,
antiarrhythmics, antihyperlipidemics.

Unit II

Drugs acting on haemopoeitic system: Haematinics, Vit. K and anticoagulants, fibrinolytics and
antiplatelet drugs, plasma volume expanders.
Drugs acting on respiratory system: Anti-asthmatic drugs, antitussives and expectorants,
respiratory stimulants.

Unit III

Autocoids: Histamine, 5HT and its antagonists, prostaglandins, thromboxane, leukotrienes,
angiotensin, bradykinin.

Unit IV

NSAIDS, Anti-gout drugs, diuretics, immunomodulators, anticancer agents.

Unit V

Drugs acting on GIT: Antacids and antiulcer drugs, laxatives and anti-diarrhoeal agents, emetics
and anti-emetics.

BOP-363P

PHARMACOLOGY-II PRACTICAL

1. To record the dose response curve (DRC) of Acetylcholine using chicken ileum.
2. To study the parallel shift of DRC in presence of competitive antagonist on DRC of
Acetylcholine using chicken ileum.
3. To study effect of Physostigmine on DRC of acetylcholine using chicken ileum.
4. To study the CRC of Histamine on guinea pig ileum. 5. Study of the effect of antihistaminics using software.

BOOKS RECOMMENDED

1. Katzung, B.G. Basic and Clinical Pharmacology, Prentice Hall International. 2. Barar F.S.K., Text Book of Pharmacology, Interprint, New Delhi.
3. Rang M.P. Dale M.M., Riter J.M., Pharmacology Churchill Livingstone.
4. Tripathi, K.D. Essentials of Medical Pharmacology, Jay Pee Publishers, New Delhi.
5. Satoskar & Bhandarkar; Pharmacology & Pharmacotherapeutics, Popular Prakashan Pvt. Ltd.,
Bombay. 6. Kulkarni S.K., Hand Book of Experimental Pharmacology, Vallabh Prakashan, Delhi.
7. Bothra S.B., Essentials of Experimental Pharmacology, Vol. 1, General Concepts, PharmaMed
Press.
8. Ghosh, M.N., Fundamentals of Experimental Pharmacology, Scientific Book Agency,
Calcutta.
9. Grover J.K., Experiments in Pharmacy and Pharmacology, CBS Publishers, New Delhi.
10. Goodman and Gilman, The Pharmacological basis of Therapeutics, Edited by Hardman J.G. 11. Laurence, D.R. and Bannet P.N., Clinical Pharmacology, Churchill Livingstone.
12. Craig, C.R. and Stitzel, R.R., Modern Pharmacology, Little Brown and Co. 13. Sheffield Bioscience Programs, U.K., ISBN, 1-874758-02-6.
14. Udaykumar Padmaja, Medical Pharmacology, CBS Publishers, New Delhi.
15. Saif S. R., Pharmacology Review, CBS Publishers, New Delhi.
16. Gupta P.K., Essential Concepts in Toxicology, PharmaMed Press. 17. Mukhopadhyay K., Undergratuate Pharmacology, CBS Publishers, New Delhi.
18. Pillai K.K., Experimental Pharmacology, CBS Publishers, New Delhi

BOP-364

PHARMACOGNOSY-III

Unit I

Phytochemical screening
A. Introduction, principles and types of extraction methods/techniques.
B. An introduction to active constituents of drugs: Classification, isolation, properties and
qualitative chemical tests of alkaloids, saponins, cardenolides and bufadienolides, cynogenetic
glycosides, flavanoids and leucoanthocyanidine.

Unit II

Study of the biological sources, commercial varieties, chemical constituents, uses, diagnostic
macroscopic and microscopic features, substitutes/adulterants and specific chemical tests of drugs
containing the following glycosides- Saponins: Liquorice, Ginseng, Dioscorea, Coleus species.
Cardioactive sterols: Digitals, Squill, Stropanthus, Thevetia.
Anthraquinone cathartics: Aloe, Senna, Rhubarb, Cascara.

Unit III

Tannins: Study of tannins and tannin containing drugs like gumbir (pale catechu), black catechu,
gall and myrobalans (Harde, Baheda, Arjuna and Ashoka).

Unit IV

Plant bitters and sweeteners: Introduction to plant bitters and sweeteners, biological source,
chemical nature and therapeutic uses of bitter and sweetener principles of the following drugs- Plant bitters: Chiratin (Momordica charantia), rotenone (Derris elliptica), limonin and naringin
(Citrus fruits).
Plant sweeteners: Thaumatin (Thaumatococcus danielli), stevioside and rebaudioside (Stevia
rebaudiana), neohesperidin (Citrus aurantium).

Unit V

Study of traditional drugs: Common vernacular name, biological sources, morphology,
chemical nature of chief constituents, common uses and pharmacology of the following
indigenous drugs: Psoralea, Gentian, Saffron, Chirata, Quassia, Amla, Kantkari, Shatavari,
Tylophora, Bhilwa, Punarnava, Chitrak, Apamarg, Gokhru, Shankhpushpi, Brahmi, Methi,
Lehsun, Palash, Gymnema, Shilajit, Nagarmotha.

BOP-364P
PHARMACOGNOSY-III PRACTICAL

1. Morphology and microscopy (powder) of Liquorice along with its chemical tests.
2. Morphology of Aloe and chemical tests on Aloe-extract.
3. Morphology and microscopy (powder) of Rhubarb. 4. Morphology of Psoralia, Saffron and Chirata.
5. Morphology of Amla, Kantkari, Shatavari and Vach.
6. Morphology of Punarnava, Apamarg, Gokhru, and Shankhpushpi.
7. Morphology of Brahmi, Methi, Lehsun and Palash.
a) Morphology of Nagarmotha and Neem.
b) Identification Tests for Guggul lipids.
8. Test for identification of glycosides (saponin and anthraquinone).
9. Test for identification of tannins.
10. Tests for identification of steroids.
11. Tests for identification of flavonoids.
12. A report on marketed preparations based on traditional drugs mentioned in theory.

BOOKS RECOMMENDED

1. Trease, G.E., and Evans, W.C., Pharmacognosy, Bailliere Tindall East Baorne, U.K.
2. Wallis. T.E. “Text Book of Pharmacognosy” J&A Churchill Ltd. London.
3. Kokate C.K., Gokhale A.S., Gokhale S.B., Cultivation of Medicinal Plants, Nirali Prakashan.
4. Tyler V.E., Lynnr B. and Robbers J.E., Pharmacognosy, 8
th Edition, Lea & Febiger,
Philadelphia.
5. Harborne J.B., Phytochemical method, Chapman & Hall International Edition, London.
6. Medicinal Plants of India, Vol. I & II, Indian Council of Medical Reasearch, New Delhi.
7. Nadkarni A.K., Indian Materia Medica, Vol- 1&2, Popular Prakashan (P) Ltd. Bombay.
8. Sukh Dev, A Selection of Prime Ayurvedic Plant Drug, Anamaya Publisher New Delhi.
9. Indian Herbal Pharmacopoeia, Vol. I & II, ICMR & RRL, Jammu.
10. Indian Ayurvedic Pharmacopoeia, Govt. of India.
11. The Wealth of India, Raw Materials (All volumes) Council of Scientific & Industrial
Research, New Delhi.
12. Rastogi R. P. and Mehrotra B.N., Compendium of Indian Medicinal Plants I-IV, Publications
& Information Directorate/Central Drug Research Institute, New Delhi. 13. American Herbal Pharmacopoeia, Botanical Pharmacognosy: Microscopic Characterization of
Botanical Medicines, Taylor & Francis Group.
14. Wallis T.E., Analytical Microscopy, J&A Churchill Ltd., London.
15. Kokate C.K., Practical Pharmacognosy, Vallabh Prakashan, New Delhi.
16. Iyengar M.A., Pharmacognosy of Powdered Crude Drugs, PharmaMed Press.
17. Iyengar, M.A. and Nayak S.C.K., Anatomy of Powdered Crude Drugs, PharmaMed Press.

BOP-365

PROFESSIONAL COMMUNICATION

Unit I

Written skills:
a. Proposal writing formats.
b. Report writing. c. Business letters. d. Applications. e. Covering letters.
f. Curriculum Vitae designing. Unit II
a. Barriers to communication, time management simulation exercise. b. Leadership skills.
c. Team work BSC (Boss, subordinates and colleagues). Unit III
1. Group discussions (GDs). a. Tips.
b. GD. 2. Non verbal aspects of communication. Unit IV
a. Corporate communication, corporate expectation, office etiquettes.
b. Extempore. Unit V
1. Interview Tips:
a. What should be done before the interview, during the interview, after the interview and on
the day of interview?
b. Various questions that may be asked in an interview.
c. Model interview (video-shooting and displaying optional). 2. Exit interview.

BOOKS RECOMMEDNDED

1. Raman M. and Sharma, S., Technical Communications- Principles & Practice, 2
nd Edition,
Oxford University Press. 2. Sharma, R. C. and Krishna Mohan, Business Correspondence and Report Writing, Tata
McGraw Hill Co.
3. Lesikar, R.V., Pettit J.V., Flateley M.E., Lesikar’s Basic Business Communication, 8th Edition,
McGraw Hill Companies.

BOP-366P

INDUSTRIAL TRAINING

The training shall include training at an approved pharmaceutical unit for a minimum of 30 days. The industrial training shall compose of observation of various manufacturing sections,
packaging section and testing section. It shall also include the study of GMP requirements, SOPs,
batch production records (BPRs), analysis records etc.
May be performed at the end of the 5
th semester.

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